Urine Parameters in Patients with COVID-19 Infection

Maria Morello; Dominga Amoroso; Felicia Losacco; Marco Viscovo; Massimo Pieri; Sergio Bernardini; Gaspare Adorno

doi:10.3390/life13081640

Urine Parameters in Patients with COVID-19 Infection

Life (Basel). 2023 Jul 28;13(8):1640. doi: 10.3390/life13081640.

Authors

Maria Morello^{1

2

3}, Dominga Amoroso^{1

2}, Felicia Losacco^{1

2}, Marco Viscovo^{1

2}, Massimo Pieri^{1

2

3}, Sergio Bernardini^{1

2

3}, Gaspare Adorno^{2

4}

Affiliations

¹ Clinical Biochemistry Department of Laboratory Medicine, Division of Proteins, University Hospital (PTV), 00133 Rome, Italy.
² Clinical Pathology and Clinical Biochemistry, Graduate School, Faculty of Medicine, University of Tor Vergata, 00133 Rome, Italy.
³ Department of Experimental Medicine, Faculty of Medicine, University of Tor Vergata, 00133 Rome, Italy.
⁴ Department of Biomedicine and Prevention, University of Rome, 00133 Rome, Italy.

Abstract

A urine test permits the measure of several urinary markers. This is a non-invasive method for early monitoring of potential kidney damage. In COVID-19 patients, alterations of urinary markers were observed. This review aims to evaluate the utility of urinalysis in predicting the severity of COVID-19. A total of 68 articles obtained from PubMed studies reported that (i) the severity of disease was related to haematuria and proteinuria and that (ii) typical alterations of the urinary sediment were noticed in COVID-19-associated AKI patients. This review emphasizes that urinalysis and microscopic examination support clinicians in diagnosing and predicting COVID-19 severity.

Keywords: COVID-19 infection; acute kidney injury (AKI); biomarkers; inflammatory cytokines; urinalysis; urine parameters.

Publication types

Review

Grants and funding

This research received no external funding.