Partial Reversible Inhibition of Enzymes and Its Metabolic and Pharmaco-Toxicological Implications

Patrick Masson; Aliya R Mukhametgalieva

doi:10.3390/ijms241612973

Partial Reversible Inhibition of Enzymes and Its Metabolic and Pharmaco-Toxicological Implications

Int J Mol Sci. 2023 Aug 19;24(16):12973. doi: 10.3390/ijms241612973.

Authors

Patrick Masson¹, Aliya R Mukhametgalieva¹

Affiliation

¹ Biochemical Neuropharmacology Laboratory, Kazan Federal University, 18 ul. Kremlevskaya, 420008 Kazan, Russia.

Abstract

Partial reversible inhibition of enzymes, also called hyperbolic inhibition, is an uncommon mechanism of reversible inhibition, resulting from a productive enzyme-inhibitor complex. This type of inhibition can involve competitive, mixed, non-competitive and uncompetitive inhibitors. While full reversible inhibitors show linear plots for reciprocal enzyme initial velocity versus inhibitor concentration, partial inhibitors produce hyperbolic plots. Similarly, dose-response curves show residual fractional activity of enzymes at high doses. This article reviews the theory and methods of analysis and discusses the significance of this type of reversible enzyme inhibition in metabolic processes, and its implications in pharmacology and toxicology.

Keywords: hyperbolic inhibition; inhibition diagnosis; partial reversible inhibition; substrate inhibition.

Publication types

Review

MeSH terms

Multienzyme Complexes*

Substances

Multienzyme Complexes

Grants and funding

The work of P. Masson was carried out in accordance with the Strategic Academic Leadership Program “Priority 2030” of the Kazan Federal University of the Government of the Russian Federation.