Methods for Radiolabeling Nanoparticles (Part 3): Therapeutic Use

Biomolecules. 2023 Aug 12;13(8):1241. doi: 10.3390/biom13081241.

Abstract

Following previously published systematic reviews on the diagnostic use of nanoparticles (NPs), in this manuscript, we report published methods for radiolabeling nanoparticles with therapeutic alpha-emitting, beta-emitting, or Auger's electron-emitting isotopes. After analyzing 234 papers, we found that different methods were used with the same isotope and the same type of nanoparticle. The most common type of nanoparticles used are the PLGA and PAMAM nanoparticles, and the most commonly used therapeutic isotope is 177Lu. Regarding labeling methods, the direct encapsulation of the isotope resulted in the most reliable and reproducible technique. Radiolabeled nanoparticles show promising results in metastatic breast and lung cancer, although this field of research needs more clinical studies, mainly on the comparison of nanoparticles with chemotherapy.

Keywords: cancer therapy; nanoparticles; nanotechnology; nuclear medicine; radiolabeling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Dendrimers / chemical synthesis
  • Dendrimers / chemistry
  • Isotope Labeling* / methods
  • Nanomedicine* / methods
  • Nanoparticles* / chemistry
  • Radioisotopes* / analysis
  • Radioisotopes* / chemistry

Substances

  • Actinium-225
  • Astatine-211
  • Copper-64
  • Dendrimers
  • Gold-198
  • Iodine-131
  • Lutetium-177
  • Radioisotopes
  • Radium-223
  • Yttrium-90

Grants and funding

This research was funded by Associazione Italiana per la Ricerca sul Cancro, grant number AIRC IG-Grant 20411, and supported by Nuclear Medicine Discovery.