The Diagnosis and Non-pharmacological Management of Acute Kidney Injury in Patients with Cirrhosis

Nikhilesh R Mazumder; Shilpa Junna; Pratima Sharma

doi:10.1016/j.cgh.2023.04.033

The Diagnosis and Non-pharmacological Management of Acute Kidney Injury in Patients with Cirrhosis

Clin Gastroenterol Hepatol. 2023 Sep;21(10S):S11-S19. doi: 10.1016/j.cgh.2023.04.033.

Authors

Nikhilesh R Mazumder¹, Shilpa Junna², Pratima Sharma³

Affiliations

¹ Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan; Gastroenterology Section, VA Ann Arbor Healthcare System, Ann Arbor, Michigan.
² Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan.
³ Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan; Gastroenterology Section, VA Ann Arbor Healthcare System, Ann Arbor, Michigan. Electronic address: pratimas@med.umich.edu.

PMID: 37625862
DOI: 10.1016/j.cgh.2023.04.033

Abstract

Acute kidney injury in patients with cirrhosis is quite common, and is seen in up to 50% of patients hospitalized for decompensated cirrhosis. Causes of acute kidney injury include prerenal, renal, or postrenal etiologies. The diagnosis and early institution of nonpharmacologic and pharmacologic management are key to the recovery of renal function. The objective of this review is to provide a practical approach to the use of diagnostic biomarkers and highlight the nonpharmacologic management and prevention of acute kidney injury.

Keywords: Biomarkers; Cirrhosis; Hepatorenal Syndrome; NGAL; Portal Hypertension.

Published by Elsevier Inc.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Acute Kidney Injury* / diagnosis
Acute Kidney Injury* / etiology
Acute Kidney Injury* / therapy
Health Facilities
Humans
Kidney
Liver Cirrhosis* / complications
Liver Cirrhosis* / diagnosis
Liver Cirrhosis* / therapy
Patients