Rethinking neutrophil extracellular traps

Yi Liu; Yu-Hua Ma; Jian-Wei Yang; Jiang-Wei Man; Hua-Bin Wang; Yi Li; Cheng Liang; Jin-Long Cao; Si-Yu Chen; Kun-Peng Li; Li Yang

doi:10.1016/j.intimp.2023.110834

Rethinking neutrophil extracellular traps

Int Immunopharmacol. 2023 Nov;124(Pt A):110834. doi: 10.1016/j.intimp.2023.110834. Epub 2023 Aug 23.

Authors

Yi Liu¹, Yu-Hua Ma¹, Jian-Wei Yang¹, Jiang-Wei Man¹, Hua-Bin Wang¹, Yi Li¹, Cheng Liang¹, Jin-Long Cao¹, Si-Yu Chen¹, Kun-Peng Li¹, Li Yang²

Affiliations

¹ Department of Urology, The Second Hospital of Lanzhou University, Gansu Province Clinical Research Center for Urology, Second Clinical School Lanzhou University, China.
² Department of Urology, The Second Hospital of Lanzhou University, Gansu Province Clinical Research Center for Urology, Second Clinical School Lanzhou University, China. Electronic address: ery_yangli@lzu.edu.cn.

PMID: 37625368
DOI: 10.1016/j.intimp.2023.110834

Abstract

Neutrophils are a major subset of leukocytes in human circulating blood. In some circumstances, neutrophils release neutrophil extracellular traps (NETs). lnitially, NETs were considered to have a strong antibacterial capacity. However, currently, NETs have been shown to have a pivotal impact on various diseases. Different stimulators induce the production of different types of NETs, and their biological functions and modes of clearance do not appear to be the same. In this review, we will discuss several important issues related to NETs in order to better understand the relationship between NETs and diseases, as well as how to utilize the characteristics of NETs for disease treatment.

Keywords: DNase; Extracellular DNA; Fibrosis; Leukotoxic hypercitrullination; Macrophage; Mitochondrial DNA; Neutrophil extracellular traps (NETs).

Publication types

Review