Design and manufacturing of biomimetic scaffolds for bone repair inspired by bone trabeculae

Deyin Kong; Qing Wang; Jiangeng Huang; Zhihui Zhang; Xiebin Wang; Qing Han; Yanbin Shi; Ran Ji; Yiling Li

doi:10.1016/j.compbiomed.2023.107369

Design and manufacturing of biomimetic scaffolds for bone repair inspired by bone trabeculae

Comput Biol Med. 2023 Oct:165:107369. doi: 10.1016/j.compbiomed.2023.107369. Epub 2023 Aug 18.

Authors

Deyin Kong¹, Qing Wang¹, Jiangeng Huang¹, Zhihui Zhang², Xiebin Wang³, Qing Han⁴, Yanbin Shi⁵, Ran Ji¹, Yiling Li¹

Affiliations

¹ Key Laboratory of Bionic Engineering, Ministry of Education, College of Biological and Agricultural Engineering, Jilin University, Changchun, China.
² Key Laboratory of Bionic Engineering, Ministry of Education, College of Biological and Agricultural Engineering, Jilin University, Changchun, China; Liaoning Academy of Materials, Shenyang 110167, China. Electronic address: zhzh@jlu.edu.cn.
³ Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University, Jinan, China.
⁴ Department of Orthopedics, Second Hospital of Jilin University, Changchun, China.
⁵ School of Mechanical & Automotive Engineering, Qilu University of Technology, Shandong Academy of Sciences, Jinan, China.

PMID: 37625259
DOI: 10.1016/j.compbiomed.2023.107369

Abstract

Porous scaffold (PorS) implants, particularly those that mimic the structural features of natural cancellous bone (NCanB), are increasingly essential for the treatment of large-area bone defects. However, the mechanical properties of NCanB-based bionic bone scaffold (BioS) and its performance as a bone repair material have not been fully explored. This study investigates the effect of bionic structure parameters on the mechanical properties and bone reconstruction performance of BioS. Using laser powder bed fusion (L-PBF) technology, different BioS with various structural parameters were created and evaluated using Micro-CT, compression testing, Finite Element (FE) Simulation, and computational fluid dynamics (CFD), and compared to commonly used clinical PorS. Assess the capacity of the BioS scaffold to support and enhance bone reconstruction following implantation through the evaluation of its mechanical properties, permeability, and fluid shear stress (FSS). BioS-85-90 and BioS-80-50 showed suitable mechanical properties, performed well in FE simulation of implantation, demonstrated outstanding abilities for osteoinductive ingrowth and bone tissue differentiation, and proved to be reliable materials for the reconstruction of bone defects. Therefore, BioS shows significant potential for clinical application as a bone reconstruction material, providing a solid foundation for the integration of tissue engineering and bionic design.

Keywords: Bionic trabecular bone scaffold; Bone defects; Bone reconstruction materials; Finite element methods; Laser powder bed fusion.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomimetics*
Bone and Bones* / surgery
Materials Testing
Porosity
Prostheses and Implants
Tissue Engineering