Isoniazid and Rifampicin Resistance-Conferring Mutations in Mycobacterium tuberculosis Isolates from South Africa

Afsatou Ndama Traoré; Mpumelelo Casper Rikhotso; Marry Avheani Mphaphuli; Sana Mustakahmed Patel; Hafsa Ali Mahamud; Leonard Owino Kachienga; Jean-Pierre Kabue; Natasha Potgieter

doi:10.3390/pathogens12081015

Isoniazid and Rifampicin Resistance-Conferring Mutations in Mycobacterium tuberculosis Isolates from South Africa

Pathogens. 2023 Aug 4;12(8):1015. doi: 10.3390/pathogens12081015.

Authors

Afsatou Ndama Traoré¹, Mpumelelo Casper Rikhotso¹, Marry Avheani Mphaphuli¹, Sana Mustakahmed Patel¹, Hafsa Ali Mahamud¹, Leonard Owino Kachienga¹, Jean-Pierre Kabue¹, Natasha Potgieter¹

Affiliation

¹ Department of Biochemistry and Microbiology, Faculty of Sciences, Engineering & Agriculture, University of Venda, Thohoyandou 0950, South Africa.

Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tb), remains a significant global health issue, with high morbidity and mortality rates. The emergence of drug-resistant strains, particularly multidrug-resistant TB (MDR-TB), poses difficult challenges to TB control efforts. This comprehensive review and meta-analysis investigated the prevalence of and molecular insights into isoniazid (INH) and rifampicin (RIF) resistance-conferring mutations in M. tb isolates from South Africa. Through systematic search and analysis of 11 relevant studies, we determined the prevalence of gene mutations associated with RIF and INH resistance, such as rpoB, katG, and inhA. The findings demonstrated a high prevalence of specific mutations, including S450L in rpoB, and S315T, which are linked to resistance against RIF and INH, respectively. These results contribute to the understanding of drug resistance mechanisms and provide valuable insights for the development of targeted interventions against drug-resistant TB.

Keywords: INH; RIF; drug resistance mechanisms; resistance-conferring mutations; tuberculosis.

Publication types

Review

Grants and funding

Research reported in this article was supported by the South African Medical Research Council (SAMRC) through its Division of Research Capacity Development under the Research Capacity Development Initiative from funding received from the South African National Treasury. The content and findings reported/illustrated are the sole deduction, view and responsibility of the researcher and do not reflect the official position and sentiments of the SAMRC.