New Sorbicillinoids from the Mangrove Endophytic Fungus Trichoderma reesei SCNU-F0042

Jialin Li; Tao Chen; Jianchen Yu; Hao Jia; Chen Chen; Yuhua Long

doi:10.3390/md21080442

New Sorbicillinoids from the Mangrove Endophytic Fungus Trichoderma reesei SCNU-F0042

Mar Drugs. 2023 Aug 5;21(8):442. doi: 10.3390/md21080442.

Authors

Jialin Li¹, Tao Chen¹, Jianchen Yu², Hao Jia¹, Chen Chen¹, Yuhua Long¹

Affiliations

¹ GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, School of Chemistry, South China Normal University, Guangzhou 510006, China.
² Key Laboratory of Tropical Disease Control, Ministry of Education, Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China.

Abstract

Three new dimeric sorbicillinoids (1-3) and one new 3,4,6-trisubstituted α-pyrone (5), along with seven analogues (4 and 6-11), were isolated from the mangrove endophytic fungus Trichoderma reesei SCNU-F0042 under the guidance of molecular networking approach. Their chemical structures were established by 1D and 2D NMR HR-ESI-MS and ECD analysis. In a bioassay, compound 2 exhibited moderate SARS-CoV-2 inhibitory activity with an EC₅₀ value of 29.0 μM.

Keywords: SARS-CoV-2 inhibitory activity; Trichoderma reesei; mangrove endophytic fungus; molecular networking; sorbicillinoids.

New Sorbicillinoids from the Mangrove Endophytic Fungus Trichoderma reesei SCNU-F0042

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