Intrauterine growth pattern in Butajira HDSS, Southern Ethiopia: BUNMAP pregnancy cohort

Yalemwork G Mengistu; Damen Hailemariam; Meselech A Roro; Bilal S Endris; Kokeb Tesfamariam; Seifu H Gebreyesus

doi:10.1186/s12887-023-04244-2

Intrauterine growth pattern in Butajira HDSS, Southern Ethiopia: BUNMAP pregnancy cohort

BMC Pediatr. 2023 Aug 24;23(1):422. doi: 10.1186/s12887-023-04244-2.

Authors

Yalemwork G Mengistu¹, Damen Hailemariam², Meselech A Roro³, Bilal S Endris⁴, Kokeb Tesfamariam⁵, Seifu H Gebreyesus⁴

Affiliations

¹ Department of Public Health Nutrition and Dietetics, School of Public Health, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia. yalemworkgetnet@gmail.com.
² Department of Health Systems Management and Health Policy, School of Public Health, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
³ Department of Reproductive, Family and Population Health, School of Public Health, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
⁴ Department of Public Health Nutrition and Dietetics, School of Public Health, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
⁵ Department of Public Health, College of Medicine and Public Health, Ambo University, Ambo, Ethiopia.

Abstract

Background: Abnormal fetal growth pattern during pregnancy including excessive fetal size and intrauterine growth restrictions are the major determinants for perinatal outcomes and postnatal growth. Ultrasonography is a useful tool in monitoring fetal growth for appropriate care and interventions. However, there are few longitudinal studies using serial ultrasonography in low and middle-income countries. Moreover, the reference charts used for fetal growth monitoring in low-income countries comes from high income countries with distinct population features. Therefore, the purpose of this study was to evaluate the intrauterine growth pattern of the fetus using serial ultrasonography.

Methods: We conducted a prospective community-based cohort study from March 2018 to December 2019. Pregnant women with gestational age of 24 weeks or below living in the Butajira HDSS were enrolled. We followed the pregnant women until delivery. Serial ultrasound measurements were taken, and fetal weight was estimated using the Hadlock algorithm based on biparietal diameter, head circumference, abdominal circumference, and femur length. The z-scores and percentiles of biometric measurements were calculated and compared to the INTERGROWTH-21^st International Standards for Fetal Growth.

Results: We reviewed a total of 2055 ultrasound scans and 746 women who fulfill the inclusion criteria were involved". We found similar distribution patterns of biometric measurements and estimated fetal weight compared to the previous study done in Ethiopia, the WHO and INTERGROWTH-21^st references. In our study, the 5^th,50^th and 95^th percentiles of estimated fetal weight distribution have a similar pattern to the WHO and INTERGROWTH-21^st charts. The 50^th and 95^th percentile had also a similar distribution pattern with the previous study conducted in Ethiopia. We found that 10% of the fetus were small for gestational age (below the 10^th percentile) based on the Z-score of estimated fetal weight.

Conclusion: Our study evaluated the fetal growth patterns in rural community of Ethiopia using serial ultrasound biometric measurements. We found similar IUG patterns to the WHO and INTERGROWTH-21^st reference standards as well as the previous study conducted in Ethiopia.

Keywords: BUNMAP; Cohort study Ethiopia; Fetal growth; Growth pattern; Intrauterine growth; Longitudinal study; Ultrasound.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cohort Studies
Ethiopia
Female
Fetal Growth Retardation / diagnostic imaging
Fetal Weight*
Fetus*
Humans
Infant
Pregnancy
Prospective Studies