Mechanisms controlling the mechanical properties of the nuclei

Giulia Bastianello; Marco Foiani

doi:10.1016/j.ceb.2023.102222

Mechanisms controlling the mechanical properties of the nuclei

Curr Opin Cell Biol. 2023 Oct:84:102222. doi: 10.1016/j.ceb.2023.102222. Epub 2023 Aug 22.

Authors

Giulia Bastianello¹, Marco Foiani²

Affiliations

¹ IFOM, The FIRC Institute of Molecular Oncology, Milan 20139, Italy; Oncology and Haemato-Oncology Department, University of Milan, Milan 20122, Italy. Electronic address: giulia.bastianello@ifom.eu.
² IFOM, The FIRC Institute of Molecular Oncology, Milan 20139, Italy; Oncology and Haemato-Oncology Department, University of Milan, Milan 20122, Italy. Electronic address: marco.foiani@ifom.eu.

PMID: 37619290
DOI: 10.1016/j.ceb.2023.102222

Abstract

The mechanical properties of the nucleus influence different cellular and nuclear functions and have relevant implications for several human diseases. The nucleus protects genetic information while acting as a mechano-sensory hub in response to internal and external forces. Cells have evolved mechano-transduction signaling to respond to physical cellular and nuclear perturbations and adopted a multitude of molecular pathways to maintain nuclear shape stability and prevent morphological abnormalities of the nucleus. Here we describe those key biological processes that control nuclear mechanics and discuss emerging perspectives on the mechanobiology of the nucleus as a diagnostic tool and clinical target.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biophysics
Cell Nucleus*
Humans
Signal Transduction*