Regulation of Ryanodine Receptor-Dependent Neurotransmitter Release by AIP, Calstabins, and Presenilins

Zhao-Wen Wang; Longgang Niu; Sadaf Riaz

doi:10.1007/978-3-031-34229-5_11

Regulation of Ryanodine Receptor-Dependent Neurotransmitter Release by AIP, Calstabins, and Presenilins

Adv Neurobiol. 2023:33:287-304. doi: 10.1007/978-3-031-34229-5_11.

Authors

Zhao-Wen Wang¹, Longgang Niu², Sadaf Riaz²

Affiliations

¹ Department of Neuroscience, University of Connecticut School of Medicine, Farmington, CT, USA. zwwang@uchc.edu.
² Department of Neuroscience, University of Connecticut School of Medicine, Farmington, CT, USA.

PMID: 37615871
DOI: 10.1007/978-3-031-34229-5_11

Abstract

Ryanodine receptors (RyRs) are Ca²⁺ release channels located in the endoplasmic reticulum membrane. Presynaptic RyRs play important roles in neurotransmitter release and synaptic plasticity. Recent studies suggest that the proper function of presynaptic RyRs relies on several regulatory proteins, including aryl hydrocarbon receptor-interacting protein, calstabins, and presenilins. Dysfunctions of these regulatory proteins can greatly impact neurotransmitter release and synaptic plasticity by altering the function or expression of RyRs. This chapter aims to describe the interaction between these proteins and RyRs, elucidating their crucial role in regulating synaptic function.

Keywords: AIP; AIPR-1; Aryl hydrocarbon receptor-interacting protein; Calstabin1; Calstabin2; FKBP12; FKBP12.6; Presenilin; Ryanodine receptor.

MeSH terms

Biological Transport
Humans
Neuronal Plasticity
Neurotransmitter Agents
Presenilins*
Ryanodine
Ryanodine Receptor Calcium Release Channel*

Substances

Ryanodine Receptor Calcium Release Channel
Presenilins
Ryanodine
Neurotransmitter Agents

Grants and funding

R01 NS109388/NS/NINDS NIH HHS/United States