Heatstroke-induced acute kidney injury and the innate immune system

Hiroyasu Goto; Manabu Kinoshita; Naoki Oshima

doi:10.3389/fmed.2023.1250457

Heatstroke-induced acute kidney injury and the innate immune system

Front Med (Lausanne). 2023 Aug 8:10:1250457. doi: 10.3389/fmed.2023.1250457. eCollection 2023.

Authors

Hiroyasu Goto¹, Manabu Kinoshita², Naoki Oshima¹

Affiliations

¹ Department of Nephrology and Endocrinology, National Defense Medical College, Tokorozawa, Japan.
² Department of Immunology and Microbiology, National Defense Medical College, Tokorozawa, Japan.

Abstract

Heatstroke can cause multiple organ failure and systemic inflammatory response syndrome as the body temperature rises beyond the body's ability to regulate temperature in a hot environment. Previous studies have indicated that heatstroke-induced acute kidney injury (AKI) can lead to chronic kidney disease. Therefore, there is an urgent need to elucidate the mechanism of heatstroke-induced AKI and to establish methods for its prevention and treatment. Recent reports have revealed that innate immunity, including neutrophils, macrophages, lymphocytes, and mast cells, is deeply involved in heat-induced AKI. In this review, we will discuss the roles of each immune cell in heat-induced renal injury and their potential therapeutic use.

Keywords: NK cells; NKT (natural killer T) cells; heat-related illness (HRI); macrophage; mast cell (MC); neutrophil.

Publication types

Review