Biomedical applications of engineered heparin-based materials

Ehsan Nazarzadeh Zare; Danial Khorsandi; Atefeh Zarepour; Hulya Yilmaz; Tarun Agarwal; Sara Hooshmand; Reza Mohammadinejad; Fatma Ozdemir; Onur Sahin; Sevin Adiguzel; Haroon Khan; Ali Zarrabi; Esmaeel Sharifi; Arun Kumar; Ebrahim Mostafavi; Negar Hosseinzadeh Kouchehbaghi; Virgilio Mattoli; Feng Zhang; Vadim Jucaud; Alireza Hassani Najafabadi; Ali Khademhosseini

doi:10.1016/j.bioactmat.2023.08.002

Biomedical applications of engineered heparin-based materials

Bioact Mater. 2023 Aug 10:31:87-118. doi: 10.1016/j.bioactmat.2023.08.002. eCollection 2024 Jan.

Authors

Ehsan Nazarzadeh Zare¹, Danial Khorsandi², Atefeh Zarepour³, Hulya Yilmaz⁴, Tarun Agarwal⁵, Sara Hooshmand⁴, Reza Mohammadinejad⁶, Fatma Ozdemir⁴, Onur Sahin⁷, Sevin Adiguzel⁴, Haroon Khan⁸, Ali Zarrabi³, Esmaeel Sharifi^{9

10}, Arun Kumar¹¹, Ebrahim Mostafavi^{12

13}, Negar Hosseinzadeh Kouchehbaghi², Virgilio Mattoli¹⁴, Feng Zhang¹⁵, Vadim Jucaud², Alireza Hassani Najafabadi², Ali Khademhosseini²

Affiliations

¹ School of Chemistry, Damghan University, Damghan, 36716-45667, Iran.
² Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90024, United States.
³ Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Sariyer, Istanbul, 34396, Turkey.
⁴ Nanotechnology Research and Application Center (SUNUM), Sabanci University, Istanbul, 34956, Turkey.
⁵ Department of Bio-Technology, Koneru Lakshmaiah Education Foundation, Vaddeswaram, AP, India.
⁶ Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran.
⁷ Department of Basic Pharmacy Sciences, Faculty of Pharmacy, Istinye University, Istanbul, Turkey.
⁸ Department of Pharmacy, Abdul Wali Khan University, Mardan, 23200, Pakistan.
⁹ Department of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran.
¹⁰ Institute of Polymers, Composites and Biomaterials - National Research Council (IPCB-CNR), Viale J.F. Kennedy 54 - Mostra D'Oltremare pad. 20, 80125, Naples, Italy.
¹¹ Chitkara College of Pharmacy, Chitkara University, Punjab, India.
¹² Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
¹³ Stanford Cardiovascular Institute, Stanford University, School of Medicine, Stanford, CA, 94305, USA.
¹⁴ Istituto Italiano di Tecnologia, Centre for Materials Interfaces, Viale Rinaldo Piaggio 34, Pontedera, Pisa, 56025, Italy.
¹⁵ The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, 324000, Zhejiang, China.

Abstract

Heparin is a negatively charged polysaccharide with various chain lengths and a hydrophilic backbone. Due to its fascinating chemical and physical properties, nontoxicity, biocompatibility, and biodegradability, heparin has been extensively used in different fields of medicine, such as cardiovascular and hematology. This review highlights recent and future advancements in designing materials based on heparin for various biomedical applications. The physicochemical and mechanical properties, biocompatibility, toxicity, and biodegradability of heparin are discussed. In addition, the applications of heparin-based materials in various biomedical fields, such as drug/gene delivery, tissue engineering, cancer therapy, and biosensors, are reviewed. Finally, challenges, opportunities, and future perspectives in preparing heparin-based materials are summarized.

Keywords: Biological; Biomedical applications; Heparin; Nanomaterials; Physicochemical; Preparation.

Publication types

Review