Erianin: A phytoestrogen with therapeutic potential

Gangmin Li; Huiqiong Zhang; Hui Lai; Gang Liang; Jiang Huang; Fulan Zhao; Xiaofang Xie; Cheng Peng

doi:10.3389/fphar.2023.1197056

Erianin: A phytoestrogen with therapeutic potential

Front Pharmacol. 2023 Aug 7:14:1197056. doi: 10.3389/fphar.2023.1197056. eCollection 2023.

Authors

Gangmin Li¹, Huiqiong Zhang², Hui Lai¹, Gang Liang¹, Jiang Huang¹, Fulan Zhao¹, Xiaofang Xie³, Cheng Peng³

Affiliations

¹ Department of Pharmacy, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China.
² Safety Evaluation Center, Sichuan Institute for Drug Control (Sichuan Testing Center of Medical Devices), Chengdu, China.
³ State Key Laboratory of Traditional Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Abstract

Erianin, a phytoestrogen with therapeutic potential, is one of the major active components of Dendrobll caulis. Erianin has a variety of pharmacological effects, such as anti-tumor, anti-inflammatory, anti-diabetic retinopathy, anti-psoriasis, and antibacterial effects. Especially, in regard to the anti-tumor effect of erianin, the underlying molecular mechanism has been partly clarified. In fact, the numerous pharmacological actions of erianin are complex and interrelated, mainly including ERK1/2, PI3K/Akt, JAK2/STAT3, HIF-1α/PD-L1, PPT1/mTOR, JNK/c-Jun, and p38 MAPK signal pathway. However, on account of the poor water solubility and the low bioavailability of erianin, greatly affected and limited its further development and application. And it is worthwhile and meaningful to explore more extensive pharmacological effects and mechanisms, clarify pharmacokinetics, and synthesize the derivatives of erianin. Conclusively, in this paper, the pharmacological effects of erianin and its mechanism, pharmacokinetics, and derivatives studies were reviewed, in order to provide a reference for the development and application of erianin.

Keywords: anti-tumour effect; derivatives; erianin; mechanism; pharmacokinetics.

Publication types

Review

Grants and funding

This study was supported by Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (No: ZYYCXTD-D-202209); Multidimensional evaluation of characteristic traditional Chinese medicine resources and product development innovation team (2022C001); the National Natural Science Foundation of China (no. 81891012); Study on Authenticity of Genuine Medicinal Materials in Sichuan (U19A2010).