Immunology: NACHT domain proteins get a prokaryotic origin story

Nicole D Marino; Igor E Brodsky

doi:10.1016/j.cub.2023.06.084

Immunology: NACHT domain proteins get a prokaryotic origin story

Curr Biol. 2023 Aug 21;33(16):R875-R878. doi: 10.1016/j.cub.2023.06.084.

Authors

Nicole D Marino¹, Igor E Brodsky²

Affiliations

¹ Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: ndmarino@alumni.stanford.edu.
² Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA. Electronic address: ibrodsky@vet.upenn.edu.

PMID: 37607487
DOI: 10.1016/j.cub.2023.06.084

Abstract

The NACHT domain is found in eukaryotic pattern recognition receptors that promote anti-microbial defense, mediating their oligomerization into immune signaling complexes. Kibby et al. uncover a superfamily of prokaryotic NACHT-containing proteins and demonstrate that some members of this family mediate anti-phage defense.

Publication types

Comment

MeSH terms

Bacteriophages* / genetics
Eukaryota
Eukaryotic Cells
Prokaryotic Cells
Signal Transduction