Acquired Immune Deficiency Syndrome correlation with SARS-CoV-2 N genotypes

Iñigo Ximeno-Rodríguez; Irene Blanco-delRío; Egoitz Astigarraga; Gabriel Barreda-Gómez

doi:10.1016/j.bj.2023.100650

Acquired Immune Deficiency Syndrome correlation with SARS-CoV-2 N genotypes

Biomed J. 2023 Aug 19:100650. doi: 10.1016/j.bj.2023.100650. Online ahead of print.

Authors

Iñigo Ximeno-Rodríguez¹, Irene Blanco-delRío², Egoitz Astigarraga³, Gabriel Barreda-Gómez⁴

Affiliations

¹ Ixilka Biotech S.L, Bizkaia, Spain. Electronic address: iximeno@ixilka.net.
² Ixilka Biotech S.L, Bizkaia, Spain.
³ Research and Development Department, IMG Pharma Biotech S.L, Derio, 48160, Bizkaia, Spain.
⁴ Research and Development Department, IMG Pharma Biotech S.L, Derio, 48160, Bizkaia, Spain. Electronic address: egoitz.astigarraga@imgpharma.com.

PMID: 37604249
DOI: 10.1016/j.bj.2023.100650

Abstract

Epigenetics and clinical observations referring to Betacoronavirus lead to the conjecture that Sarvecovirus may have the ability to infect lymphocytes using a different way than the spike protein. In addition to inducing the death of lymphocytes, thus drastically reducing their population and causing a serious immune deficiency, allows it to remain hidden for long periods of latency using them as a viral reservoir in what is named Long-Covid Disease. Exploring possibilities, the hypothesis is focused on that N protein may be the key of infecting lymphocytes. Method The present article exhibits a computational assay for the latest complete sequences reported to GISAID, correlating N genotypes with an enhancement in the affinity of the complex that causes immune deficiency in order to determine a good docking with the N protein and some receptors in lymphocytes. Results A novel high-interaction coupling of N-RBD and CD147 is presented as the main way of infecting lymphocytes, allowing to define those genotypes involved in their affinity enhancement. Conclusion The hypothesis is consistent with the mutagenic deriving observed on the in-silico assay, which reveals that genotypes N/120 and N/152 are determinant to reduce the Immune Response of the host infecting lymphocytes, allowing the virus persists indefinitely and causing an Acquire Immune Deficiency Syndrome.

Keywords: AIDS; Acquired Immune Deficiency Syndrome; Artificial Intelligence; Bioinformatics; Long-Covid Disease; SARS-CoV-2.