A new semiconductor heterojunction SERS substrate for ultra-sensitive detection of antibiotic residues in egg

Huizhu Zhang; Yimin Tang; Weie Wang; Dongxue Yu; Libin Yang; Xin Jiang; Wei Song; Bing Zhao

doi:10.1016/j.foodchem.2023.137163

A new semiconductor heterojunction SERS substrate for ultra-sensitive detection of antibiotic residues in egg

Food Chem. 2024 Jan 15:431:137163. doi: 10.1016/j.foodchem.2023.137163. Epub 2023 Aug 15.

Authors

Huizhu Zhang¹, Yimin Tang², Weie Wang³, Dongxue Yu³, Libin Yang⁴, Xin Jiang⁵, Wei Song⁶, Bing Zhao⁷

Affiliations

¹ College of Chemistry and Chemical Engineering, Technology Innovation Center of Industrial Hemp for State Market Regulation, Qiqihar University, Qiqihar 161006, China; College of Pharmacy, Jiamusi University, Jiamusi 154007, China.
² College of Chemistry and Chemical Engineering, Technology Innovation Center of Industrial Hemp for State Market Regulation, Qiqihar University, Qiqihar 161006, China.
³ College of Pharmacy, Jiamusi University, Jiamusi 154007, China.
⁴ College of Chemistry and Chemical Engineering, Technology Innovation Center of Industrial Hemp for State Market Regulation, Qiqihar University, Qiqihar 161006, China. Electronic address: yanglibin@qqhru.edu.cn.
⁵ College of Chemistry and Chemical Engineering, Technology Innovation Center of Industrial Hemp for State Market Regulation, Qiqihar University, Qiqihar 161006, China. Electronic address: jiangxin@qqhru.edu.cn.
⁶ State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, China. Electronic address: weisong@jlu.edu.cn.
⁷ State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, China. Electronic address: zhaob@jlu.edu.cn.

PMID: 37603998
DOI: 10.1016/j.foodchem.2023.137163

Abstract

Antibiotic residues in animal-derived food (egg) are threatening human health. Semiconductor heterojunction surface-enhanced Raman scattering (SERS) substrates can be used for ultra-sensitive detection of antibiotic residues in egg. Here, a TiO₂/ZnO heterojunction was developed as a new SERS substrate based on an interface engineering strategy. Due to strong interfacial coupling and efficient carrier separating in heterostructure, utilization rate of photo-induced electrons in substrate was improved greatly, which realized the efficient charge transfer in substrate-molecule system, resulting in a prominent SERS enhancement. Taking the detection of enrofloxacin residue in egg as an example, the limit of detection (LOD) is only 13.1 μg/kg, which is far below the European Union standard, and lower than LODs of other conventional analytical methods and existing noble metal-based SERS methods. More importantly, benefiting from high sensitivity and selectivity of heterojunction and fingerprint characteristics of SERS, multiple antibiotic residues in egg can be identified simultaneously.

Keywords: Animal-derived food; Antibiotic residue; SERS; Substrate; TiO(2)/ZnO heterojunction.

MeSH terms

Animal Feed*
Animals
Anti-Bacterial Agents*
Electrons
Enrofloxacin
Humans
Semiconductors

Substances

Anti-Bacterial Agents
Enrofloxacin