Over the past three decades, the perception of hydrogen sulfide (H2S) in living organisms has changed drastically. From being considered a toxic molecule, H2S is now considered a multifunctional signaling molecule that is involved directly or indirectly in a myriad of physiological processes in animal and plant cells but also in the mechanism of responses against adverse or pathological situations that usually have associated cellular oxidative stress. This Forum editorial introduces a set of articles (four reviewers and a research article) that emphasizes the relevance of H2S in the research area of plants and mammals as well as it also highlights the future directions of investigations. Antioxid. Redox Signal. 39, 980-982.
Keywords: hydrogen sulfide; persulfidation; persulfides; polysulfides; signaling.