Unrevealing the Role of TLRs in the Pathogenesis of Autoimmune Disease by Using Mouse Model of Diabetes

Eleonora Panfili; Elena Orecchini; Giada Mondanelli

doi:10.1007/978-1-0716-3366-3_11

Unrevealing the Role of TLRs in the Pathogenesis of Autoimmune Disease by Using Mouse Model of Diabetes

Methods Mol Biol. 2023:2700:187-198. doi: 10.1007/978-1-0716-3366-3_11.

Authors

Eleonora Panfili¹, Elena Orecchini², Giada Mondanelli³

Affiliations

¹ Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
² Department of Onco-Hematology and Cell and Gene Therapy, Bambin Gesù Children's Hospital, IRCCS, Rome, Italy.
³ Department of Medicine and Surgery, University of Perugia, Perugia, Italy. giada.mondanelli@unipg.it.

PMID: 37603182
DOI: 10.1007/978-1-0716-3366-3_11

Abstract

Toll-like receptors (TLRs) are receptors of the innate immune system specialized in recognizing conserved molecular pattern of pathogens and initiating an appropriate immune response. Along with the recognition of foreign materials, TLRs have also been shown to respond to endogenous molecules, thus mediating the development of autoimmune diseases. Type 1 diabetes (T1D) is a prototypic autoimmune disease in which TLRs play a pathogenic role. We here describe a protocol to study the role of TLRs in the development and progression of T1D by resorting to the nonobese diabetic (NOD) mouse model.

Keywords: Autoimmune diseases; Nonobese diabetic (NOD) mice; Toll-like receptors; Type 1 diabetes.

MeSH terms

Animals
Autoimmune Diseases*
Diabetes Mellitus, Type 1*
Disease Models, Animal
Mice
Toll-Like Receptors

Substances

Toll-Like Receptors