Follow up duration of phase III Multiple Myeloma Clinical Trials: A systematic review

EJHaem. 2023 Jun 29;4(3):719-722. doi: 10.1002/jha2.680. eCollection 2023 Aug.

Abstract

Long-term follow-up of multiple myeloma (MM) clinical trials are needed to assess long-term outcomes. We aimed to investigate the length of follow-up of all phase III MM clinical trials. Median follow-up duration of clinical trials of newly diagnosed MM was longer when compared to relapsed/refractory MM clinical trials (42.7 vs. 20.5 months, respectively). The follow-up duration of phase III clinical trials in MM is relatively short when compared to the improved outcomes in the current era. Efforts should be made to facilitate long-term clinical trials follow-up and/or publication of results of updated results.

Keywords: clinical trials; follow‐up duration; long‐term follow‐up; multiple myeloma.