ROS induced lipid peroxidation and their role in ferroptosis

Hiwot Tezera Endale; Winta Tesfaye; Tiget Ayelgn Mengstie

doi:10.3389/fcell.2023.1226044

ROS induced lipid peroxidation and their role in ferroptosis

Front Cell Dev Biol. 2023 Aug 1:11:1226044. doi: 10.3389/fcell.2023.1226044. eCollection 2023.

Authors

Hiwot Tezera Endale¹, Winta Tesfaye², Tiget Ayelgn Mengstie²

Affiliations

¹ Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
² Department of Human Physiology, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Abstract

Reactive oxygen species (ROS) play a crucial part in the process of cell death, including apoptosis, autophagy, and ferroptosis. ROS involves in the oxidation of lipids and generate 4-hydroxynonenal and other compounds associated with it. Ferroptosis may be facilitated by lipid peroxidation of phospholipid bilayers. In order to offer novel ideas and directions for the investigation of disorders connected to these processes, we evaluate the function of ROS in lipid peroxidation which ultimately leads to ferroptosis as well as proposed crosstalk mechanisms between ferroptosis and other types programmed cell death.

Keywords: ROS; apoptosis; autophagy; ferroptosis; lipid peroxidation.

Publication types

Review