Under the influence: environmental factors as modulators of neuroinflammation through the IL-10/IL-10R axis

Front Immunol. 2023 Aug 3:14:1188750. doi: 10.3389/fimmu.2023.1188750. eCollection 2023.

Abstract

The IL-10/IL-10 receptor (IL-10R) axis plays an important role in attenuating neuroinflammation in animal models of Multiple Sclerosis (MS) and increased IL-10 has been associated with a positive response to MS disease modifying therapy. Because environmental factors play an important role in MS susceptibility and disease course, identification of environmental factors that impact the IL-10/IL-10R axis has therapeutic potential. In this review, we provide historical and updated perspectives of how IL-10R signaling impacts neuroinflammation, discuss environmental factors and intestinal microbes with known impacts on the IL-10/IL-10R axis, and provide a hypothetical model for how B cells, via their production of IL-10, may be important in conveying environmental "information" to the inflamed central nervous system.

Keywords: B cells; IL-10; IL-10R; central nervous system; environmental factors; experimental autoimmune encephalomyelitis; multiple sclerosis.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • B-Lymphocytes
  • Central Nervous System
  • Interleukin-10*
  • Multiple Sclerosis* / etiology
  • Neuroinflammatory Diseases
  • Receptors, Interleukin-10

Substances

  • Interleukin-10
  • Receptors, Interleukin-10

Grants and funding

The authors acknowledge funding from the MS Society of Canada for an operating grant (EGID#920164) to JG and an EndMS Doctoral award (EGID#3490) to AW.