Research progress of mitophagy in chronic cerebral ischemia

Mayue Yu; Manqing Zhang; Peijie Fu; Moxin Wu; Xiaoping Yin; Zhiying Chen

doi:10.3389/fnagi.2023.1224633

Research progress of mitophagy in chronic cerebral ischemia

Front Aging Neurosci. 2023 Aug 3:15:1224633. doi: 10.3389/fnagi.2023.1224633. eCollection 2023.

Authors

Mayue Yu^#^{1

2}, Manqing Zhang^#³, Peijie Fu^{1

2}, Moxin Wu^{1

2}, Xiaoping Yin^{1

2}, Zhiying Chen^{1

2}

Affiliations

¹ Department of Neurology, Clinical Medical School of Jiujiang University, Jiujiang, Jiangxi, China.
² Jiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, China.
³ School of Basic Medicine, Jiujiang University, Jiujiang, Jiangxi, China.

^# Contributed equally.

Abstract

Chronic cerebral ischemia (CCI), a condition that can result in headaches, dizziness, cognitive decline, and stroke, is caused by a sustained decrease in cerebral blood flow. Statistics show that 70% of patients with CCI are aged > 80 years and approximately 30% are 45-50 years. The incidence of CCI tends to be lower, and treatment for CCI is urgent. Studies have confirmed that CCI can activate the corresponding mechanisms that lead to mitochondrial dysfunction, which, in turn, can induce mitophagy to maintain mitochondrial homeostasis. Simultaneously, mitochondrial dysfunction can aggravate the insufficient energy supply to cells and various diseases caused by CCI. Regulation of mitophagy has become a promising therapeutic target for the treatment of CCI. This article reviews the latest progress in the important role of mitophagy in CCI and discusses the induction pathways of mitophagy in CCI, including ATP synthesis disorder, oxidative stress injury, induction of reactive oxygen species, and Ca²⁺ homeostasis disorder, as well as the role of drugs in CCI by regulating mitophagy.

Keywords: chronic cerebral ischemia; mitochondrial autophagy; oxidative stress; stroke; treatment.

Publication types

Review

Grants and funding

This study was supported partially by the National Natural Science Foundation of China (81960221 and 82260249 to XY), the National Science & Technology Fundamental Resource Investigation Program of China (2018FY100903 to XY), the Jiangxi Provincial Health Commission Science and Technology Plan project (202311506 to ZC), the Jiangxi Provincial Administration of Traditional Chinese Medicine Science and Technology Plan project (2022A322 to ZC), the Key Projects of Jiangxi Provincial Department of Education (GJJ2201902 to ZC), and the Youth Foundation of Natural Science Foundation of Jiangxi Province (20224BAB216045 to ZC).