Evaluating the effects of PeakATP® supplementation on visuomotor reaction time and cognitive function following high-intensity sprint exercise

Jessica M Moon; Trevor J Dufner; Adam J Wells

doi:10.3389/fnut.2023.1237678

Evaluating the effects of PeakATP^® supplementation on visuomotor reaction time and cognitive function following high-intensity sprint exercise

Front Nutr. 2023 Aug 4:10:1237678. doi: 10.3389/fnut.2023.1237678. eCollection 2023.

Authors

Jessica M Moon¹, Trevor J Dufner¹, Adam J Wells¹

Affiliation

¹ Exercise Physiology, Intervention, and Collaboration Lab, School of Kinesiology and Rehabilitation Sciences, University of Central Florida, Orlando, FL, United States.

Abstract

The purpose of this study was to examine the effects of 14-days adenosine 5'-triphosphate (ATP) supplementation (PeakATP^®) on reaction time (RT), multiple object tracking speed (MOT), mood and cognition. Twenty adults (22.3 ± 4.4 yrs., 169.9 ± 9.5 cm, 78.7 ± 14.6 kg) completed two experimental trials in a double-blind, counter-balanced, crossover design. Subjects were randomized to either PeakATP^® (400 mg) or placebo (PLA) and supplemented for 14-days prior to each trial. During each trial, subjects completed a three-minute all-out test on a cycle ergometer (3MT), with measures of visuomotor RT [Dynavision D2 Proactive (Mode A) and Reactive (Mode B) tasks], MOT (Neurotracker), mood (Profile of Mood States Questionnaire; POMS) and cognition (Automated Neuropsychological Assessment Metrics; ANAM) occurring before (PRE), immediately post (IP) and 60 min post-3MT (60P). Subjects ingested an acute dose of the assigned supplement 30 min prior to completing PRE assessments for each trial. Trials were separated by a 14-day washout period. PeakATP^® significantly attenuated declines in hits (p = 0.006, η_p² = 0.235) and average RT (AvgRT, p = 0.006, η_p² = 0.236) in Mode A, significantly improved AvgRT (p = 0.039, η_p² = 0.174) in Mode B, and significantly reduced the total number of misses (p = 0.005, η_p² = 0.343) in Mode B. No differences between treatments were noted for MOT, POMS or ANAM variables. In conclusion, these results indicate that PeakATP^® maintains proactive RT and improves reactive RT following high-intensity sprint exercise suggesting that supplemental ATP may mitigate exercise induced cognitive dysfunction.

Keywords: ATP; cognition; mood; multiple object tracking; performance.