Phytochemical investigation of aerial parts of Woodsia ilvensis and its plasmin-inhibitory activity in vitro

Punsantsogvoo Otgonsugar; Buyanmandakh Buyankhishig; Tserendorj Undrakhbayar; Byambajav Bilguun; Kenroh Sasaki; Bekh-Ochir Davaapurev; Javzan Batkhuu; Tseesuren Byambajav; Toshihiro Murata

doi:10.1016/j.phytochem.2023.113826

Phytochemical investigation of aerial parts of Woodsia ilvensis and its plasmin-inhibitory activity in vitro

Phytochemistry. 2023 Nov:215:113826. doi: 10.1016/j.phytochem.2023.113826. Epub 2023 Aug 19.

Authors

Punsantsogvoo Otgonsugar¹, Buyanmandakh Buyankhishig², Tserendorj Undrakhbayar³, Byambajav Bilguun⁴, Kenroh Sasaki⁵, Bekh-Ochir Davaapurev⁶, Javzan Batkhuu⁶, Tseesuren Byambajav³, Toshihiro Murata⁷

Affiliations

¹ Division of Pharmacognosy, Tohoku Medical and Pharmaceutical University, 4-1 Komatsushima 4-chome Aoba-ku, Sendai, 981-8558, Japan; Laboratory of Pharmacology and Toxicology, Institute of Veterinary Medicine, Mongolian University of Life Sciences, POB-24, Ulaanbaatar, 17024, Mongolia.
² Graduate School, National University of Mongolia, POB-617/46A, Ulaanbaatar, 14201, Mongolia; School of Engineering and Applied Sciences, National University of Mongolia, POB-617/46A, Ulaanbaatar, 14201, Mongolia.
³ Laboratory of Pharmacology and Toxicology, Institute of Veterinary Medicine, Mongolian University of Life Sciences, POB-24, Ulaanbaatar, 17024, Mongolia.
⁴ Laboratory of Metabolism and Biochemistry, Institute of Veterinary Medicine, Mongolian University of Life Sciences, POB-24, Ulaanbaatar, 17024, Mongolia.
⁵ Division of Pharmacognosy, Tohoku Medical and Pharmaceutical University, 4-1 Komatsushima 4-chome Aoba-ku, Sendai, 981-8558, Japan.
⁶ School of Engineering and Applied Sciences, National University of Mongolia, POB-617/46A, Ulaanbaatar, 14201, Mongolia.
⁷ Division of Pharmacognosy, Tohoku Medical and Pharmaceutical University, 4-1 Komatsushima 4-chome Aoba-ku, Sendai, 981-8558, Japan. Electronic address: murata-t@tohoku-mpu.ac.jp.

PMID: 37598993
DOI: 10.1016/j.phytochem.2023.113826

Abstract

The fern plant Woodsia ilvensis (L.) R. Br. belongs to the Woodsiaceae family and its leaves are used to treat diarrhea, soft-tissue injuries, and external injuries. Investigations of the compounds obtained from the plasmin-inhibitory-active extracts of W. ilvensis led to the isolation of two undescribed maleimide N-glycosides, an undescribed stilbenoid glycoside, and five undescribed acetylated flavonol bisdesmosides, together with 19 known compounds. The chemical structures of the isolated compounds were determined using spectroscopy. The absolute configurations of the sugar moieties were determined via HPLC after acid hydrolysis. Among the isolated compounds, some flavonoids and stilbenoid glycosides exhibited plasmin-inhibitory activity.

Keywords: Maleimide N-glycosides; Plasmin-inhibitory flavonoids; Stilbenoid glycoside; Woodsia ilvensis; Woodsiaceae.

MeSH terms

Ferns* / chemistry
Fibrinolysin* / analysis
Flavonoids / chemistry
Glycosides / chemistry
Molecular Structure
Phytochemicals* / chemistry
Phytochemicals* / isolation & purification
Phytochemicals* / pharmacology
Plant Components, Aerial / chemistry
Plant Extracts* / chemistry

Substances

Fibrinolysin
Flavonoids
Glycosides
Plant Extracts
Phytochemicals