[What to do when faced with a chronic elevation of transaminases]

A Delamarre; G Boillet; V de Lédinghen

doi:10.1016/j.revmed.2023.07.009

[What to do when faced with a chronic elevation of transaminases]

Rev Med Interne. 2023 Oct;44(10):555-560. doi: 10.1016/j.revmed.2023.07.009. Epub 2023 Aug 17.

[Article in French]

Authors

A Delamarre¹, G Boillet², V de Lédinghen³

Affiliations

¹ Service d'hépatologie et de transplantation hépatique, hôpital Haut-Lévêque, centre hospitalier universitaire de Bordeaux, Bordeaux, France; BRIC, Inserm U1312, université de Bordeaux, Bordeaux, France.
² Service d'hépatologie et de transplantation hépatique, hôpital Haut-Lévêque, centre hospitalier universitaire de Bordeaux, Bordeaux, France.
³ Service d'hépatologie et de transplantation hépatique, hôpital Haut-Lévêque, centre hospitalier universitaire de Bordeaux, Bordeaux, France; BRIC, Inserm U1312, université de Bordeaux, Bordeaux, France. Electronic address: victor.deledinghen@chu-bordeaux.fr.

PMID: 37597973
DOI: 10.1016/j.revmed.2023.07.009

Abstract

Chronic elevation of transaminases is recurring issue in primary care. This article aims to be practical. It offers a quick reminder of epidemiology, pathophysiology, concept of normal values of transaminases, main causes (alcohol, fatty liver disease, viral hepatitis) and first-line assessment. Then, we will go further in less frequent causes, extra-hepatic causes and additional tests. We will precise what is the role of general practitioner in this care pathway and when to address patient to specialist.

Keywords: Alcohol; Alcool; Fibrose; Fibrosis; Hépatite virale; NAFLD; Transaminases; Viral hepatitis.

Publication types

English Abstract
Review