Segmental extracellular-to-intracellular water resistance ratio and physical function in older adults

Yujiro Asano; Taishi Tsuji; Tomohiro Okura

doi:10.1016/j.exger.2023.112278

Segmental extracellular-to-intracellular water resistance ratio and physical function in older adults

Exp Gerontol. 2023 Oct 1:181:112278. doi: 10.1016/j.exger.2023.112278. Epub 2023 Aug 19.

Authors

Yujiro Asano¹, Taishi Tsuji², Tomohiro Okura³

Affiliations

¹ Doctoral Program in Physical Education, Health and Sport Science, Degree Programs in Comprehensive Human Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8574, Japan.
² Institute of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8574, Japan. Electronic address: tsuji.taishi.gn@u.tsukuba.ac.jp.
³ Institute of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8574, Japan; R&D Center for Tailor-Made QOL, University of Tsukuba, 1-2 Kasuga, Tsukuba, Ibaraki 305-8550, Japan.

PMID: 37597709
DOI: 10.1016/j.exger.2023.112278

Abstract

Objectives: This study aimed to investigate the association between whole-body (WB), arm, and leg extracellular-to-intracellular water resistance (Recw/Ricw) ratios and various physical functions of each segment and muscle mass using segmental multifrequency bioelectrical impedance analysis.

Methods: In total, 988 community-dwelling older adults were included in the analysis. Physical function was assessed using hand grip, 5-repetition sit-to-stand, 5-m habitual walk, Timed Up and Go, and single-leg balance with eyes open tests. Each segmental Recw/Ricw ratio and muscle mass were assessed at 5 and 250 kHz resistances using a segmental multifrequency bioelectrical impedance analysis device. Pearson's correlation between the segmental Recw/Ricw ratio and muscle mass and physical function was calculated, and the difference in correlation coefficients was tested using Bonferroni correction. Multiple linear regression analysis was conducted using physical function as the dependent variable and the segmental Recw/Ricw ratio as the independent variable, adjusting for sex, age, body mass index, and segmental muscle mass.

Results: WB and leg Recw/Ricw ratios were significantly positively correlated with good hand grip performance, gait speed, mobility, balance, and standing power (p < 0.05), after adjusting for sex, age, body mass index, and muscle mass. Furthermore, the leg Recw/Ricw ratio was positively associated with lower extremity physical function compared with WB and arm Recw/Ricw ratios and muscle mass (p < 0.01). Conversely, WB muscle mass was more strongly related to grip strength than WB, arm, and leg Recw/Ricw ratios (p < 0.01).

Conclusions: The Recw/Ricw ratio is useful for identifying older adults with worse physical function. The Recw/Ricw ratio allows for easy and timely screening of older adults with worse physical function in clinical settings.

Keywords: Bioelectrical impedance analysis; Body composition; Muscle function; Muscle quality.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Body Mass Index
Hand Strength*
Independent Living*
Linear Models
Water

Substances

Water