Alternative splicing events and function in the tumor microenvironment: New opportunities and challenges

Xueyi Song; Xuehao Li; Yuexin Ge; Jia Song; Qian Wei; Miao He; Minjie Wei; Yining Zhang; Tianbao Chen; Lin Zhao

doi:10.1016/j.intimp.2023.110718

Alternative splicing events and function in the tumor microenvironment: New opportunities and challenges

Int Immunopharmacol. 2023 Oct:123:110718. doi: 10.1016/j.intimp.2023.110718. Epub 2023 Aug 17.

Authors

Xueyi Song¹, Xuehao Li², Yuexin Ge³, Jia Song⁴, Qian Wei⁵, Miao He⁶, Minjie Wei⁷, Yining Zhang⁸, Tianbao Chen⁹, Lin Zhao¹⁰

Affiliations

¹ Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang 110122, PR China. Electronic address: 1317110911@qq.com.
² Department of thoracic surgery, The First Affiliated Hospital of China Medical University, Shenyang, China. Electronic address: xhli92@cmu.edu.cn.
³ Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang 110122, PR China. Electronic address: 1621914066@qq.com.
⁴ Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang 110122, PR China. Electronic address: 2294465620@qq.com.
⁵ Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang 110122, PR China. Electronic address: 584950932@qq.com.
⁶ Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang 110122, PR China. Electronic address: hemiao_cmu@126.com.
⁷ Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang 110122, PR China. Electronic address: mjwei@cmu.edu.cn.
⁸ Department of Gastroenterology, the First Affiliated Hospital of China Medical University, Shenyang, China. Electronic address: zhangyining@cmu.edu.cn.
⁹ Natural Drug Discovery Group, School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, Northern Ireland. Electronic address: UK.t.chen@qub.ac.uk.
¹⁰ Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang 110122, PR China. Electronic address: lzhao@cmu.edu.cn.

PMID: 37597404
DOI: 10.1016/j.intimp.2023.110718

Abstract

Alternative splicing controls gene expression at the transcriptional level, producing structurally and functionally distinct protein heterodimers. Aberrant alternative splicing greatly affects cell development and plays an important role in the invasion and metastasis of many types of cancer. Recently, it has been shown that alternative splicing can alter the tumor microenvironment and regulate processes such as remodeling, immunity, and inflammation in the tumor microenvironment. However, there is no comprehensive literature review of the complex relationship between alternative splicing and the tumor microenvironment. Therefore, this review aims to collect all the latest data on this topic and provide a new perspective on the therapeutic and potential prognostic markers of cancer.

Keywords: Alternative splicing; Cancer; Tumor microenvironment.

Publication types

Review

MeSH terms

Alternative Splicing*
Cell Differentiation
Humans
Inflammation
Neoplasms* / genetics
Tumor Microenvironment / genetics