The PCOS puzzle: putting the pieces together for optimal care

Int J Adolesc Med Health. 2023 Aug 21;35(4):299-311. doi: 10.1515/ijamh-2023-0102. eCollection 2023 Aug 1.

Abstract

Polycystic ovary syndrome (PCOS) is a multifaceted hormonal disorder that has significant ramifications for both women's reproductive and metabolic well-being. This analysis aims to offer a thorough comprehension of PCOS by investigating the various contributing factors that are crucial for its effective management. We delve into the topic of hormonal imbalances, such as elevated androgens and disrupted estrogen-progesterone dynamics, and their effects on reproductive and metabolic health. Furthermore, we explore the intricate connection between insulin resistance, hyperinsulinemia, and PCOS, highlighting their pivotal role in metabolic dysfunction. Additionally, we examine fertility challenges, irregular menstrual patterns, and metabolic complications while also reviewing current treatment methodologies. Moreover, we address the latest research concerning genetic, environmental, and epigenetic influences on PCOS. By piecing together these essential elements, healthcare professionals can attain a comprehensive understanding of PCOS and deliver optimal care for those affected by the condition.

Keywords: PCOS; fertility; insulin resistance; weight management.

Publication types

  • Review

MeSH terms

  • Female
  • Health Personnel
  • Humans
  • Insulin Resistance*
  • Polycystic Ovary Syndrome*