Evolving spike mutations in SARS-CoV-2 Omicron variants facilitate evasion from breakthrough infection-acquired antibodies

Shiqi Chen; Zehong Huang; Yue Guo; Huilin Guo; Lijuan Jian; Jin Xiao; Xiangyang Yao; Hai Yu; Tong Cheng; Yali Zhang; Ming Guan; Richeng Mao; Jiming Zhang; Ningshao Xia; Quan Yuan

doi:10.1038/s41421-023-00584-6

Evolving spike mutations in SARS-CoV-2 Omicron variants facilitate evasion from breakthrough infection-acquired antibodies

Cell Discov. 2023 Aug 18;9(1):86. doi: 10.1038/s41421-023-00584-6.

Authors

Shiqi Chen^#¹, Zehong Huang^#^{2

3}, Yue Guo^#¹, Huilin Guo^#^{2

3}, Lijuan Jian^#⁴, Jin Xiao^{2

3}, Xiangyang Yao⁴, Hai Yu^{2

3}, Tong Cheng^{2

3}, Yali Zhang^{5

6}, Ming Guan⁷, Richeng Mao⁸, Jiming Zhang⁹, Ningshao Xia^{10

11}, Quan Yuan^{12

13}

Affiliations

¹ Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Shanghai Institute of Infectious Diseases and Biosecurity, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
² State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China.
³ National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, Fujian, China.
⁴ Department of Pulmonary Diseases, The First Affiliated Hospital of Xiamen University, Xiamen, China.
⁵ State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China. zhangyali@xmu.edu.cn.
⁶ National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, Fujian, China. zhangyali@xmu.edu.cn.
⁷ Department of Laboratory Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. guanming88@yahoo.com.
⁸ Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Shanghai Institute of Infectious Diseases and Biosecurity, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China. njxiaomao@163.com.
⁹ Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Shanghai Institute of Infectious Diseases and Biosecurity, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China. jmzhang@fudan.edu.cn.
¹⁰ State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China. nsxia@xmu.edu.cn.
¹¹ National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, Fujian, China. nsxia@xmu.edu.cn.
¹² State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China. yuanquan@xmu.edu.cn.
¹³ National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, Fujian, China. yuanquan@xmu.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Letter