A Comprehensive Review on Therapeutic Potential of a Natural Anthraquinone Derivative Emodin in Brain-related Disorders

Ahsas Goyal; Yogesh Murti; Bharat Bhushan; Wasim Chisti; Ashutosh Solanki

doi:10.2174/1389450124666230818092506

A Comprehensive Review on Therapeutic Potential of a Natural Anthraquinone Derivative Emodin in Brain-related Disorders

Curr Drug Targets. 2023;24(12):945-958. doi: 10.2174/1389450124666230818092506.

Authors

Ahsas Goyal¹, Yogesh Murti¹, Bharat Bhushan¹, Wasim Chisti¹, Ashutosh Solanki²

Affiliations

¹ Institute of Pharmaceutical Research, GLA University 17-Km. Stone, NH-2 Mathura-Delhi Highway, P.O. Chaumuhan, Mathura-281406, U.P., India.
² Department of Pharmacology, Anand College of Pharmacy (SGI), Agra, 282007, U.P., India.

PMID: 37594103
DOI: 10.2174/1389450124666230818092506

Abstract

Brain-related disorders are one of the world's most important and complex health problems today. These brain-related disorders are responsible for a massive number of morbidities and death all around the world. However, researchers have devoted a large amount of time to investigating these diseases and found positive results; nevertheless, there are currently quite a few medications available to treat them. Emodin (EM), a polyphenol compound, has many health benefits. It is a biologically active monomer derived from rhubarb root that exhibits anti-inflammation, anti-oxidation, anticancer, and neuroprotective properties. A series of preclinical trials have shown EM to have protective benefits against many brain-related diseases. This review has evaluated the potential of EM as a pharmacological agent for the treatment and management of various brain-related disorders based on the findings of multiple pre-clinical studies and taking into account the compound's therapeutic properties.

Keywords: Alzheimer’s disease; EM; cerebral ischemia; depression; epilepsy; glioblastoma; intra-cerebral haemorrhage; parkinson’s disease; stress; traumatic brain injury.