Molecular epidemiology of Clostridioides difficile isolates in a non-outbreak setting at a comprehensive cancer center

Neha Mehta; Jennifer M Harrington; Meghan A Wallace; Jillianna M Wasiura; Carey-Ann D Burnham; Katherine M Mullin; Brahm H Segal; Nikolaos G Almyroudis

doi:10.1017/ash.2023.156

Molecular epidemiology of Clostridioides difficile isolates in a non-outbreak setting at a comprehensive cancer center

Antimicrob Steward Healthc Epidemiol. 2023 Jul 26;3(1):e131. doi: 10.1017/ash.2023.156. eCollection 2023.

Authors

Neha Mehta¹, Jennifer M Harrington², Meghan A Wallace³, Jillianna M Wasiura², Carey-Ann D Burnham³, Katherine M Mullin⁴, Brahm H Segal⁴, Nikolaos G Almyroudis⁴

Affiliations

¹ Internal Medicine Residency Program, Jacobs School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY, USA.
² Infection Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
³ Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
⁴ Division of Infectious Diseases, Department of Internal Medicine, Roswell Park Comprehensive Cancer Center and Jacobs School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY, USA.

Abstract

Ribotyping was performed on Clostridioides difficile isolates from patients with malignancies. Thirty-one (27.9%) isolates from 111 episodes of colitis were recovered representing 14 ribotypes with 25 (80.6%) belonging to 6 ribotypes (014/020, 1/VPI/077/087, 05/015, 015/046, 05/053, 106/174). We identified three novel ribotypes with 1 carrying gene encoding for binary toxin.

Keywords: Clostridioides difficile; malignancy; molecular epidemiology; ribotyping.