Protists protecting food tolerance

Macy R Komnick; Daria Esterházy

doi:10.1016/j.it.2023.08.003

Protists protecting food tolerance

Trends Immunol. 2023 Oct;44(10):745-747. doi: 10.1016/j.it.2023.08.003. Epub 2023 Aug 15.

Authors

Macy R Komnick¹, Daria Esterházy²

Affiliations

¹ Committee on Immunology, University of Chicago, Chicago, IL, USA; Department of Pathology, University of Chicago, Chicago, IL, USA.
² Committee on Immunology, University of Chicago, Chicago, IL, USA; Department of Pathology, University of Chicago, Chicago, IL, USA. Electronic address: desterhazy@bsd.uchicago.edu.

PMID: 37591713
PMCID: PMC10987083 (available on 2024-10-01)
DOI: 10.1016/j.it.2023.08.003

Abstract

Celiac disease (CeD) is an immune disorder characterized by gluten intolerance that can be unleashed by enteric viral infections in mice. However, Sanchez-Medina et al. recently identified a murine commensal protist, Tritrichomonas arnold, that protects against reovirus-induced intolerance to dietary protein by counteracting virus-induced epithelial stress and proinflammatory dendritic cell (DC) activation.

Keywords: Celiac disease; enteric viruses; food intolerance; protist.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Celiac Disease* / metabolism
Immune Tolerance
Mice
Virus Diseases*

Abstract

Publication types

MeSH terms

Grants and funding