Abietane diterpenoids with anti-inflammatory activities from Callicarpa bodinieri

Abstract

Nine undescribed abietane diterpenoids (1-9) and eleven known abietane analogs (10-20) were isolated from Callicarpa bodinieri. Their structures were characterized by interpreting spectroscopic data, X-ray crystallography, and ECD analysis. The anti-inflammatory activities of these compounds were tested by evaluation of their inhibitory effect on NO production by lipopolysaccharide in RAW 264.7 macrophages, and compounds 3 and 8 exhibited potent anti-inflammatory activities with IC₅₀ values of 36.35 ± 1.12 and 37.21 ± 0.92 μM. The western blotting studies demonstrated that compound 3 inhibited the expression of nitric oxide synthase and p65 that involved in the NF-κB pathway.

Keywords: Abietane-type diterpenoids; Anti-inflammatory activities; Callicarpa bodinieri; Lamiaceae.