MCC950 ameliorates cognitive function by reducing white matter microstructure damage in rats after SAH

Brain Res Bull. 2023 Oct 1:202:110743. doi: 10.1016/j.brainresbull.2023.110743. Epub 2023 Aug 15.

Abstract

Neuroinflammation and white matter microstructure damage are important causes of cognitive impairment after subarachnoid hemorrhage (SAH). Nod-like receptor protein 3 (NLRP3) plays an important role in neuroinflammation after SAH and may be a potential therapeutic target for treatment of white matter microstructure injury. In this study, we observed whether MCC950, a specific inhibitor of the NLRP3 inflammasome, exerted a therapeutic effect after SAH. The SAH model was induced by endovascular perforation in SpragueDawley rats. MCC950 was injected intraperitoneally 1 h after SAH at a dose of 10 mg/kg. The results showed that MCC950 significantly attenuated white matter microstructure damage in some brain regions, and behavioral experiments confirmed that MCC950 ameliorated cognitive function in rats after SAH, which may provide a new method for the treatment of cognitive dysfunction in SAH patients.

Keywords: Cognitive function; MCC950; NLRP3 inflammasome; Subarachnoid hemorrhage; White matter microstructure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain Injuries* / metabolism
  • Cognition
  • NLR Family, Pyrin Domain-Containing 3 Protein / metabolism
  • Neuroinflammatory Diseases
  • Rats
  • Subarachnoid Hemorrhage* / complications
  • Subarachnoid Hemorrhage* / drug therapy
  • Subarachnoid Hemorrhage* / metabolism
  • Sulfonamides / pharmacology
  • White Matter* / metabolism

Substances

  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Sulfonamides