Palladium/Lewis Acid Co-catalyzed Cyclocarbonylation of (2-Aminoaryl)(aryl)methanols: An Access to 3-Aryl-indolin-2-ones

J Org Chem. 2023 Sep 1;88(17):12367-12375. doi: 10.1021/acs.joc.3c01103. Epub 2023 Aug 17.

Abstract

A benign approach to valuable 3-aryl-indolin-2-ones was developed based on palladium(II)/Lewis acid-cocatalyzed cyclocarbonylation of readily available (2-aminoaryl)(aryl)methanols. The protocol features producing water as the only byproduct, mild reaction conditions, and good efficiency, constituting an array of 3-arylindolin-2-ones in yields of 35 to 90%. The reaction can be easily scaled up to the gram scale in good yields.