Eyelid dermatitis is a common occurrence in several skin disorders, including seborrheic dermatitis, atopic dermatitis and psoriasis. However, it is primarily associated with allergic contact dermatitis (ACD). Here, we present a case of 51-year-old woman who developed pruritic erythema of the eyelids after using 0.1% Nepafenac eye drops. Nepafenac is a non-steroidal anti-inflammatory drug (NSAID) commonly prescribed as eye drops for various inflammatory eye conditions. Instances of ACD caused by Nepafenac eye drops are exceedingly rare based on available case reports. Nevertheless, it is important to consider ACD as a potential cause when a patient with eyelid dermatitis has a history of Nepafenac eye drop usage. The Naranjo algorithm, which was used for assessing causality, determined the likelihood of this case being a possible instance of ACD due to Nepafenac (Naranjo score=3).