Structure, ligands, and roles of GPR126/ADGRG6 in the development and diseases

Qi Li; Anran Huo; Mengqi Li; Jiali Wang; Qiao Yin; Lumiao Chen; Xin Chu; Yuan Qin; Yuwan Qi; Yang Li; Hengxiang Cui; Qifei Cong

doi:10.1016/j.gendis.2023.02.016

Structure, ligands, and roles of GPR126/ADGRG6 in the development and diseases

Genes Dis. 2023 Mar 27;11(1):294-305. doi: 10.1016/j.gendis.2023.02.016. eCollection 2024 Jan.

Authors

Qi Li¹, Anran Huo¹, Mengqi Li¹, Jiali Wang¹, Qiao Yin², Lumiao Chen³, Xin Chu⁴, Yuan Qin¹, Yuwan Qi¹, Yang Li⁵, Hengxiang Cui^{6

7}, Qifei Cong^{1

2}

Affiliations

¹ Institute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, Jiangsu 215123, China.
² Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China.
³ Department of Nephrology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China.
⁴ Department of Emergency Center, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
⁵ Department of Neurology, Huzhou Central Hospital, The Affiliated Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, Zhejiang 313000, China.
⁶ Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.
⁷ Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.

Abstract

Adhesion G protein-coupled receptors (aGPCRs) are the second largest diverse group within the GPCR superfamily, which play critical roles in many physiological and pathological processes through cell-cell and cell-extracellular matrix interactions. The adhesion GPCR Adgrg6, also known as GPR126, is one of the better-characterized aGPCRs. GPR126 was previously found to have critical developmental roles in Schwann cell maturation and its mediated myelination in the peripheral nervous system in both zebrafish and mammals. Current studies have extended our understanding of GPR126-mediated roles during development and in human diseases. In this review, we highlighted these recent advances in GPR126 in expression profile, molecular structure, ligand-receptor interactions, and associated physiological and pathological functions in development and diseases.

Keywords: Adhesion G protein-coupled receptor; Function; GPR126/Adgrg6; Ligand; Structure.

Publication types

Review