Association study between C10orf90 gene polymorphisms and colorectal cancer

Jian Song; Kaixuan Wang; Zhaowei Chen; Dunjing Zhong; Li Li; Liangliang Guo; Shuyong Yu

doi:10.3389/fonc.2023.1192378

Association study between C10orf90 gene polymorphisms and colorectal cancer

Front Oncol. 2023 Jul 31:13:1192378. doi: 10.3389/fonc.2023.1192378. eCollection 2023.

Authors

Jian Song¹, Kaixuan Wang², Zhaowei Chen³, Dunjing Zhong³, Li Li⁴, Liangliang Guo³, Shuyong Yu⁴

Affiliations

¹ Department of Gastroenterology, Southern University of Science and Technology Hospital, Shenzhen, Guangdong, China.
² Department of Gastroenterology, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
³ Department of Gastroenterology, Hainan Cancer Hospital, Haikou, Hainan, China.
⁴ Department of Gastrointestinal Surgery, Hainan Cancer Hospital, Haikou, Hainan, China.

Abstract

Background: Colorectal cancer (CRC) is the third most common malignant tumor in the world. The morbidity and mortality rates in Western countries have decreased, but they are still on the rise in China. C10orf90 is associated with a variety of cancers, but the correlation between C10orf90 and CRC is not yet known.

Methods: A total of 1,339 subjects were randomly enrolled in our study. After extracting their DNA, three single-nucleotide polymorphisms (SNPs) of C10orf90 were genotyped to analyze the potential relationship between these variants and CRC risk. PLINK software packages (version 1.07) were used to evaluate multiple genetic models by calculating the odds ratio (OR) and 95% confidence interval (95% CI). The best SNP-SNP interaction model was defined by the multifactor dimensionality reduction (MDR) analysis.

Results: C10orf90 rs12412320 was significantly associated with CRC risk (p = 0.006) and might be associated with the lower CRC risk (OR: 0.78; 95% CI: 0.65-0.93). The relationship of rs12412320 with lower CRC risk was found in people aged >60 years and ≤60 years, women, non-smokers, or non-drinkers. Rs11245008 in people aged ≤60 years and rs11245007 among men had a higher CRC susceptibility. Rs12412320 was related to the lower risk of advanced stages (III/IV stage), while rs11245007 might be associated with the higher risk of advanced stages (III/IV stage). Moreover, rs12412320 had the most significant relationship with the susceptibility to rectal cancer.

Conclusion: This study is the first to report between C10orf90 gene polymorphisms and CRC risk in Chinese people, which suggests that C10orf90 rs12412320 might play a crucial role in preventing CRC occurrence.

Keywords: C10orf90; clinical features; colorectal cancer; demographic characteristics; gene polymorphisms.

Grants and funding

This work was supported by 2020 Hainan Province Major Science and Technology Plan Project (ZDKJ202005) and supported by the specific research fund of The Innovation Platform for Academinicians of Hainan Province(YSPTZX202029).