Chitosan grafted polyacrylic acid doped MnO2 nanocomposite an efficient dye degrader and antimicrobial agent

Muhammad Waqas; Anum Shahzadi; Ali Haider; Anwar Ul Hamid; Mohammed M Algaradah; Hisham S M Abd-Rabboh; Muhammad Ikram

doi:10.1016/j.ijbiomac.2023.126343

Chitosan grafted polyacrylic acid doped MnO₂ nanocomposite an efficient dye degrader and antimicrobial agent

Int J Biol Macromol. 2023 Aug 14:251:126343. doi: 10.1016/j.ijbiomac.2023.126343. Online ahead of print.

Authors

Muhammad Waqas¹, Anum Shahzadi², Ali Haider³, Anwar Ul Hamid⁴, Mohammed M Algaradah⁵, Hisham S M Abd-Rabboh⁶, Muhammad Ikram⁷

Affiliations

¹ Solar Cell Applications Research Lab, Department of Physics, Government College University Lahore, Lahore 54000, Punjab, Pakistan.
² Faculty of Pharmacy, The University of Lahore, Lahore 54000, Pakistan.
³ Department of Clinical Sciences, Faculty of Veterinary and Animal Sciences, Muhammad Nawaz Shareef, University of Agriculture, 66000 Multan, Punjab, Pakistan.
⁴ Core Research Facilities, Research Institute, King Fahd University of Petroleum & Minerals, Dhahran 31261, Saudi Arabia.
⁵ Chemistry Department, King Khalid Military Academy, Riyadh 11495, Saudi Arabia.
⁶ Chemistry Department, Faculty of Science, King Khalid University, P.O.Box 9004, Abha 61413, Saudi Arabia.
⁷ Solar Cell Applications Research Lab, Department of Physics, Government College University Lahore, Lahore 54000, Punjab, Pakistan. Electronic address: dr.muhammadikram@gcu.edu.pk.

PMID: 37586627
DOI: 10.1016/j.ijbiomac.2023.126343

Abstract

Manganese dioxide (MnO₂) nanorods and (3, 6, and 9 mL) chitosan grafted polyacrylic acid (CS-g-PAA) doped MnO₂ were prepared hydrothermally. The study objective is to decrease the recombination rate of MnO₂ upon doping to enhance the dye degradation efficiency and antimicrobial activity. The doping-dependent properties of CS-g-PAA on phase identification, functional groups, optical characteristics, elemental compositions, and morphological analyses of MnO₂ nanorods were conducted using systematic characterization techniques. XRD pattern shows that MnO₂ has a tetragonal structure, with increased crystallite size (15.87 to 29.36 nm) upon doping. The TEM analysis showed that MnO₂ has nanorods and that CS-g-PAA doped MnO₂ displayed nanoflakes-like structures. The decrease in electron-hole pair recombination rate on doping was verified by PL spectroscopy, demonstrating the enhanced catalytic activity. Moreover, adding grafted binary polymers to MnO₂ inhibits bacterial cell growth by binding with the negatively charged cell wall and preventing biofilm formation. The 9 mL doped sample displayed a maximum degradation (99.27 %) in a neutral medium and 85.84 % antimicrobial efficiency against E. coli. The enoyl-acyl carrier protein reductase (FabI_{E. coli}) and DNA gyrase_{(E. coli)} were inhibited by these CS-g-PAA doped MnO₂ nanostructures (NSs), as shown by in silico molecular docking studies.

Keywords: Anti-microbial activity; Catalytic activity; Polymers-grafted.