The impact of moderate to severe osteoarthritis on the physical performance and quality of life: a cross-sectional study in Greek patients (PONOS study)

P Savvari; I Skiadas; S A Papadakis; V Psychogios; O D Argyropoulou; A P Pastroudis; G A Skarpas; A Tsoutsanis; A Garofalakis; G Katsifis; D Boumpas; D Menegas

doi:10.1186/s12891-023-06770-7

The impact of moderate to severe osteoarthritis on the physical performance and quality of life: a cross-sectional study in Greek patients (PONOS study)

BMC Musculoskelet Disord. 2023 Aug 15;24(1):651. doi: 10.1186/s12891-023-06770-7.

Authors

P Savvari¹, I Skiadas², S A Papadakis³, V Psychogios⁴, O D Argyropoulou⁵, A P Pastroudis⁶, G A Skarpas⁷, A Tsoutsanis⁸, A Garofalakis⁹, G Katsifis¹⁰, D Boumpas¹¹, D Menegas²

Affiliations

¹ Internal Medicine Department Pfizer Hellas, Neo Psychiko, 243 Mesogeion Avenue, Athens, SA, 15451, Greece. Paraskevi.Savvari@pfizer.com.
² Internal Medicine Department Pfizer Hellas, Neo Psychiko, 243 Mesogeion Avenue, Athens, SA, 15451, Greece.
³ 2nd Orthopedic Department, KAT General Hospital of Attica, Athens, Greece.
⁴ 5th Orthopedic Department, Asclepeion General Hospital, Athens, Greece.
⁵ Department of Pathophysiology, National and Kapodistrian University of Athens, Athens, Greece.
⁶ 6th Orthopedic Department, Asclepeion General Hospital, Athens, Greece.
⁷ 3rd Orthopedic Department for Sports Injuries and Regenerative Medicine, Mitera General Hospital, Athens, Greece.
⁸ 6th Orthopedic Department Hygeia Hospital, Athens, Greece.
⁹ 1st Orthopedic Department, Mitera General Hospital, Athens, Greece.
¹⁰ Rheumatology Department, Naval Hospital Athens, Athens, Greece.
¹¹ 4th Internal Medicine Department, Attikon University Hospital, Athens, Greece.

Abstract

Background: Osteoarthritis (OA) represents a leading cause of disability with limited data available for the Greek patients.

Objectives: To evaluate the impact of moderate to severe symptomatic hip/knee OA under treatment on physical performance and quality of life.

Methods: A non-interventional, cross-sectional, epidemiological study of patients with moderate/severe OA, recruited in a single visit from 9 expert sites in Athens, Greece. Assessments were based on commonly used outcome scales: the Hip disability and Osteoarthritis Outcome Score (HOOS), the Knee Injury and Osteoarthritis Outcome Score (KOOS) and the EuroQol-5-Dimensions 3-levels questionnaire (EQ-5D-3L).

Results: One hundred sixty-four patients were included in the analysis. Most of the patients were females (78.7%), with a mean age of 70.5 ± 10.2 years. Comorbidities were reported by 87.2% of patients with hypertension being the most frequently reported (53.7%), followed by dyslipidemia (31.1%), obesity (24.4%) and diabetes mellitus (23.2%). Paracetamol was the most common treatment (96%), followed by NSAIDs (75%), opioids (50%) and locally applied medications (42.7%). Both hip and knee OA patients showed substantial deterioration in health-related quality of life (QoL) and health status as reflected by the HOOS/KOOS (Function in sport and recreation was the most impaired subscale, followed by Hip- or Knee-related QoL). The mean EQ-5D-3L index score was 0.396 ± 0.319 and the mean EQ-VAS score was 52.1 ± 1.9. When compared indirectly to the local population norms our OA population had worse QoL indices.

Conclusion: Our findings suggest the functional disability and impaired QoL of Greek patients with moderate/severe hip/knee OA under treatment emphasizing the need for novel treatments that will reduce the burden of the disease.

Keywords: Health Related Quality of Life (HRQoL); Hip osteoarthritis; Joint diseases; Knee osteoarthritis; Musculoskeletal diseases.

MeSH terms

Aged
Aged, 80 and over
Cross-Sectional Studies
Female
Greece / epidemiology
Humans
Male
Middle Aged
Osteoarthritis, Hip* / diagnosis
Osteoarthritis, Hip* / drug therapy
Osteoarthritis, Hip* / epidemiology
Osteoarthritis, Knee* / diagnosis
Osteoarthritis, Knee* / epidemiology
Physical Functional Performance
Quality of Life