Association Between Sleep Duration and Stroke in Different Status of Metabolic Syndrome: A Cross-Sectional Study in Shanghai Adult Residents

Han Wu; Yang Zheng; Dan-Ni Liu; Xiao-Xia Liu; Qun-Di Yang; Qiu-Yun Su; Ying-Quan Wang; Yu-Zhuo Wang; Xue-Na La; Yan Shi; Chen Fu

doi:10.2147/NSS.S408669

Association Between Sleep Duration and Stroke in Different Status of Metabolic Syndrome: A Cross-Sectional Study in Shanghai Adult Residents

Nat Sci Sleep. 2023 Aug 9:15:639-652. doi: 10.2147/NSS.S408669. eCollection 2023.

Authors

Han Wu^#¹, Yang Zheng^#¹, Dan-Ni Liu¹, Xiao-Xia Liu¹, Qun-Di Yang¹, Qiu-Yun Su¹, Ying-Quan Wang¹, Yu-Zhuo Wang¹, Xue-Na La¹, Yan Shi^#¹, Chen Fu^#¹

Affiliation

¹ Division of Noncommunicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, People's Republic of China.

^# Contributed equally.

Abstract

Purpose: This study aimed to investigate the relationship between sleep duration (SD) and stroke, and examine the effects of SD on stroke with or without metabolic syndrome (Mets) and its components among the adult residents in Shanghai, China.

Participants and methods: A total of 20,245 participants (51.72% male, mean age 44.66 years) were included from Shanghai Chronic Disease and Risk Factors Surveillance (SCDRFS) in 2017. The weighted logistic regressions were performed to examine the associations between SD and stroke in different status of Mets and its components.

Results: The mean SD was 7.51±0.03 h/d. After adjusting for all the potential factors, SD<6 h/d (OR=1.73, 95% CI: 1.35-2.20) or ≥10 h/d (OR=1.66, 95% CI: 1.08-2.57) was significantly positively associated with stoke in the total participants; moreover, in the non-Mets group, only SD<6 h/d (OR=1.77, 95% CI: 1.19, 2.64) significantly increased the risk of stroke; while, in the Mets group, SD<6 h/d (OR=1.80, 95% CI:1.17-2.76) and ≥10 h/d (OR=1.97, 95% CI: 1.00-3.88) both had a positive significantly association with stoke. In addition, the effects of SD<6 h/d on stroke were more pronounced among those with high WC (OR=2.24, 95% CI: 1.40-3.58) and high TG (OR=2.60, 95% CI: 1.86-3.62), and the effects of SD≥10 h/d on stroke were more evident among those with high TG (OR=2.28, 95% CI: 1.02-5.08) and high FBG (OR=2.58, 95% CI: 1.30-5.10).

Conclusion: Both short and long SD were significantly positively associated with stroke in the total participants, and the associations were stronger in the Mets group; conversely, in the non-Mets group, only short SD was significantly positively associated with stroke, and no significant association was observed between long SD and stroke. Therefore, more precise sleep measures may be needed to prevent stroke according to the different status of Mets.

Keywords: Shanghai; metabolic syndrome; sleep duration; stroke.

Grants and funding

This study was financially supported by the Shanghai Municipal Health Commission and Shanghai Medical and Health Development Foundation (1. Shanghai Municipal Health Commission Youth Projects [No. 20204Y0195]; 2. New Star in Medical Circle of Shanghai – Public Health Leader Project [No. 202199]); 3. The Shanghai New Three-year Action Plan for Public Health (No. GWV-10.1-XK16).