Non-coding RNAs as skin disease biomarkers, molecular signatures, and therapeutic targets

Andrea Roso-Mares; Isabel Andújar; Tania Díaz Corpas; Bryan K Sun

doi:10.1007/s00439-023-02588-4

Non-coding RNAs as skin disease biomarkers, molecular signatures, and therapeutic targets

Hum Genet. 2023 Aug 14. doi: 10.1007/s00439-023-02588-4. Online ahead of print.

Authors

Andrea Roso-Mares^{1

2}, Isabel Andújar³, Tania Díaz Corpas^{2

4}, Bryan K Sun⁵

Affiliations

¹ Department of Dermatology, University of California San Diego, San Diego, CA, USA.
² Faculty of Medicine and Dentistry, University of Valencia, Valencia, Spain.
³ Department of Pharmacology, University of Valencia, Valencia, Spain.
⁴ Department of Dermatology, Hospital Dr Peset, Valencia, Spain.
⁵ Department of Dermatology, University of California San Diego, San Diego, CA, USA. bryansun@health.ucsd.edu.

PMID: 37580609
DOI: 10.1007/s00439-023-02588-4

Abstract

Non-coding RNAs (ncRNAs) are emerging as biomarkers, molecular signatures, and therapeutic tools and targets for diseases. In this review, we focus specifically on skin diseases to highlight how two classes of ncRNAs-microRNAs and long noncoding RNAs-are being used to diagnose medical conditions of unclear etiology, improve our ability to guide treatment response, and predict disease prognosis. Furthermore, we explore how ncRNAs are being used as both as drug targets and associated therapies have unique benefits, risks, and challenges to development, but offer a distinctive promise for improving patient care and outcomes.

Publication types

Review