Polysaccharide-based tumor microenvironment-responsive drug delivery systems for cancer therapy

Qimeng Wu; Yang Hu; Bing Yu; Hao Hu; Fu-Jian Xu

doi:10.1016/j.jconrel.2023.08.019

Polysaccharide-based tumor microenvironment-responsive drug delivery systems for cancer therapy

J Control Release. 2023 Oct:362:19-43. doi: 10.1016/j.jconrel.2023.08.019. Epub 2023 Aug 24.

Authors

Qimeng Wu¹, Yang Hu², Bing Yu¹, Hao Hu³, Fu-Jian Xu⁴

Affiliations

¹ College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao 266071, China.
² Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education, Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
³ College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao 266071, China. Electronic address: huhao@qdu.edu.cn.
⁴ Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education, Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address: xufj@mail.buct.edu.cn.

PMID: 37579973
DOI: 10.1016/j.jconrel.2023.08.019

Abstract

The biochemical indicators of tumor microenvironment (TME) that are different from normal tissues provide the possibility for constructing intelligent drug delivery systems (DDSs). Polysaccharides with good biocompatibility, biodegradability, and unique biological properties are ideal materials for constructing DDSs. Nanogels, micelles, organic-inorganic nanocomposites, hydrogels, and microneedles (MNs) are common polysaccharide-based DDSs. Polysaccharide-based DDSs enable precise control of drug delivery and release processes by incorporating TME-specific biochemical indicators. The classification and design strategies of polysaccharide-based TME-responsive DDSs are comprehensively reviewed. The advantages and challenges of current polysaccharide-based DDSs are summarized and the future directions of development are foreseen. The polysaccharide-based TME-responsive DDSs are expected to provide new strategies and solutions for cancer therapy and make important contributions to the realization of precision medicine.

Keywords: Cancer therapy; Drug delivery system; Polysaccharides; Stimulus-response; Tumor microenvironment.

Publication types

Review