Manganese level and cognitive decline in older adults with the APOE e4 allele: a preliminary study

Psychiatry Res. 2023 Sep:327:115403. doi: 10.1016/j.psychres.2023.115403. Epub 2023 Aug 10.

Abstract

This study examined the relationship between serum manganese level and cognition, and the moderating effect of apolipoprotein E ε4 (APOE4) on this relationship. A total of 164 non-demented participants underwent clinical assessments including serum manganese level and cognition [episodic memory score (EMS), non-memory score (NMS) for executive function/attention/language/ visuospatial skill, and total score (TS)]. Serum manganese × APOE4 interaction had a significant effect on EMS and TS. Serum manganese level was inversely associated with EMS and TS in APOE4-positive but not APOE4-negative participants. APOE4 should be considered a key component in Alzheimer's disease studies that included manganese imbalance as a risk factor.

Keywords: APOE4; Cognition; Manganese.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alleles
  • Alzheimer Disease* / genetics
  • Alzheimer Disease* / psychology
  • Apolipoprotein E4 / genetics
  • Apolipoproteins E / genetics
  • Cognition
  • Cognitive Dysfunction* / genetics
  • Humans
  • Manganese
  • Neuropsychological Tests

Substances

  • Manganese
  • Apolipoprotein E4
  • Apolipoproteins E