Evidence shows that acupuncture-moxibustion could promote the healing of pressure injuries (PI), but its action mechanism is not fully understood. This review summarizes the basic research literature of acupuncture-moxibustion for PI and identifies that the mechanism of acupuncture-moxibustion for PI is related with regulation of related signaling pathway target proteins, improvement of inflammatory response, modulation of vascular microenvironment, attenuation of oxidative stress damage, and inhibition of cell apoptosis. The review also points out the current limitations and future research directions. It emphasizes the need for further exploration of the upstream regulatory mechanism, specific cellular molecules, and the interactions among these molecules. A multi-level, multi-target, and multi-dimensional approach is required to fully understand the mechanism underlying the promotion of PI healing by acupuncture-moxibustion.
针灸可促进压力性损伤（PI）的愈合，但其作用机制尚未充分阐明。梳理总结针灸治疗PI基础研究文献，发现针灸促进PI愈合的效应机制与调节相关信号通路靶蛋白、改善炎性反应、调节血管微环境、抗氧化应激损伤、抑制细胞凋亡密切相关。指出目前研究的不足和未来的研究方向，认为目前尚缺乏对其上游调控机制、具体细胞分子以及各分子间相互作用机制的研究，针灸促进PI愈合机制仍需要多层次、多靶点、多维度的深入探索。.
Keywords: acupuncture-moxibustion; mechanism; pressure injury (PI); pressure ulcer.