Antimonene with a honeycomb layered structure has great application prospects in a wide spectrum of domains due to its high carrier mobility, high thermal conductivity, and layer-dependent electrical properties. Since the first successful synthesis of antimonene by epitaxy in 2015, various fabrication methods have been proposed successively. Herein, several representative synthetic methods are described in detail, including mechanical exfoliation, epitaxial growth, liquid-phase exfoliation, electrochemical exfoliation, etc. In addition, band engineering via modification strategies of antimonene, particularly intercalation and doping, is discussed based on available theoretical studies. By comparing the achieved structure characteristics and performances of these different synthesis and modification strategies, we present promising future developments and critical challenges for antimonene.