Roles and Molecular Mechanisms of Biomarkers in Hepatocellular Carcinoma with Microvascular Invasion: A Review

Xudong Zhao; Yudan Wang; Haoming Xia; Shuqiang Liu; Ziyue Huang; Risheng He; Liang Yu; Nanfeng Meng; Hang Wang; Junqi You; Jinglin Li; Judy Wai Ping Yam; Yi Xu; Yunfu Cui

doi:10.14218/JCTH.2022.00013S

Roles and Molecular Mechanisms of Biomarkers in Hepatocellular Carcinoma with Microvascular Invasion: A Review

J Clin Transl Hepatol. 2023 Oct 28;11(5):1170-1183. doi: 10.14218/JCTH.2022.00013S. Epub 2023 May 4.

Authors

Xudong Zhao¹, Yudan Wang², Haoming Xia¹, Shuqiang Liu¹, Ziyue Huang¹, Risheng He¹, Liang Yu^{1

2}, Nanfeng Meng¹, Hang Wang¹, Junqi You¹, Jinglin Li¹, Judy Wai Ping Yam², Yi Xu^{1

2

3

4

5

6

7

8

9}, Yunfu Cui¹

Affiliations

¹ Department of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
² Department of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
³ Key Laboratory of Basic Pharmacology of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, China.
⁴ Key Laboratory of Functional and Clinical Translational Medicine, Fujian Province University, Xiamen Medical College, Xiamen, Fujian, China.
⁵ Jiangsu Province Engineering Research Center of Tumor Targeted Nano Diagnostic and Therapeutic Materials, Yancheng Teachers University, Yancheng, Jiangsu, China.
⁶ Key Laboratory of Biomarkers and In Vitro Diagnosis Translation of Zhejiang province, Hangzhou, Zhejiang, China.
⁷ Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, China.
⁸ State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, China.
⁹ Key Laboratory of Intelligent Pharmacy and Individualized Therapy of Huzhou, Department of Pharmacy, Changxing People's Hospital, Changxing, Zhejiang, China.

Abstract

Hepatocellular carcinoma (HCC) being a leading cause of cancer-related death, has high associated mortality and recurrence rates. It has been of great necessity and urgency to find effective HCC diagnosis and treatment measures. Studies have shown that microvascular invasion (MVI) is an independent risk factor for poor prognosis after hepatectomy. The abnormal expression of biomacromolecules such as circ-RNAs, lncRNAs, STIP1, and PD-L1 in HCC patients is strongly correlated with MVI. Deregulation of several markers mentioned in this review affects the proliferation, invasion, metastasis, EMT, and anti-apoptotic processes of HCC cells through multiple complex mechanisms. Therefore, these biomarkers may have an important clinical role and serve as promising interventional targets for HCC. In this review, we provide a comprehensive overview on the functions and regulatory mechanisms of MVI-related biomarkers in HCC.

Keywords: Biomarkers; Hepatocellular carcinoma; Microvascular invasion; Molecular mechanism; Progress.

Publication types

Review