Microenvironment-targeted strategy steers advanced bone regeneration

Shuyue Hao; Mingkai Wang; Zhifeng Yin; Yingying Jing; Long Bai; Jiacan Su

doi:10.1016/j.mtbio.2023.100741

Microenvironment-targeted strategy steers advanced bone regeneration

Mater Today Bio. 2023 Jul 21:22:100741. doi: 10.1016/j.mtbio.2023.100741. eCollection 2023 Oct.

Authors

Shuyue Hao¹, Mingkai Wang¹, Zhifeng Yin², Yingying Jing¹, Long Bai¹, Jiacan Su^{1

3}

Affiliations

¹ Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
² Department of Orthopedics, Shanghai Zhongye Hospital, Shanghai, 201941, China.
³ Department of Orthopedic Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200444, China.

Abstract

Treatment of large bone defects represents a great challenge in orthopedic and craniomaxillofacial surgery. Traditional strategies in bone tissue engineering have focused primarily on mimicking the extracellular matrix (ECM) of bone in terms of structure and composition. However, the synergistic effects of other cues from the microenvironment during bone regeneration are often neglected. The bone microenvironment is a sophisticated system that includes physiological (e.g., neighboring cells such as macrophages), chemical (e.g., oxygen, pH), and physical factors (e.g., mechanics, acoustics) that dynamically interact with each other. Microenvironment-targeted strategies are increasingly recognized as crucial for successful bone regeneration and offer promising solutions for advancing bone tissue engineering. This review provides a comprehensive overview of current microenvironment-targeted strategies and challenges for bone regeneration and further outlines prospective directions of the approaches in construction of bone organoids.

Keywords: Biomaterials; Bone regeneration; Chemical microenvironment; Physical microenvironment; Physiological microenvironment.

Publication types

Review