Bibliometric analysis of evolutionary trends and hotspots of super-enhancers in cancer

Zhen-Chu Tang; Qiang Qu; Xin-Qi Teng; Hai-Hui Zhuang; Wei-Xin Xu; Jian Qu

doi:10.3389/fphar.2023.1192855

Bibliometric analysis of evolutionary trends and hotspots of super-enhancers in cancer

Front Pharmacol. 2023 Jul 27:14:1192855. doi: 10.3389/fphar.2023.1192855. eCollection 2023.

Authors

Zhen-Chu Tang^{1

2}, Qiang Qu^{3

4

5

6}, Xin-Qi Teng⁷, Hai-Hui Zhuang⁷, Wei-Xin Xu⁷, Jian Qu⁷

Affiliations

¹ Department of Neurology, The Second Xiangya Hospital of Central South University, Changsha, China.
² Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital of Central South University, Changsha, China.
³ Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
⁴ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
⁵ Institute of Hospital Management, Central South University, Changsha, China.
⁶ Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Changsha Medical University, Changsha, China.
⁷ Department of Pharmacy, The Second Xiangya Hospital, Institute of Clinical Pharmacy, Central South University, Changsha, China.

Abstract

Introduction: In the past decade, super-enhancer (SE) has become a research hotspot with increasing attention on cancer occurrence, development, and prognosis. To illustrate the hotspots of SE in cancer research and its evolutionary tendency, bibliometric analysis was carried out for this topic. Methods: Literature published before Dec 31, 2022, in WOSCC, was systematically classified, and Citespace, bibliometric.com/app, and GraphPad Prism analyzed the data. Results: After screening out inappropriate documents and duplicate data, 911 publications were selected for further bibliometric analysis. The top five research areas were Oncology (257, 28.211%), Cell Biology (210, 23.052%), Biochemistry Molecular Biology (209, 22.942%), Science Technology Other Topics (138, 15.148%), and Genetics Heredity (132, 14.490%). The United States of America (United States) has the highest number of documents (462, 50.71%), followed by China (303, 33.26%). Among the most productive institutions, four of which are from the United States and one from Singapore, the National University of Singapore. Harvard Medical School (7.68%) has the highest percentage of articles. Young, Richard A, with 32 publications, ranks first in the number of articles. The top three authors came from Whitehead Institute for Biomedical Research as a research team. More than two-thirds of the research are supported by the National Institutes of Health of the United States (337, 37.654%) and the United States Department of Health Human Services (337, 37.654%). And "super enhancer" (525), "cell identity" (258), "expression" (223), "cancer" (205), and "transcription factor" (193) account for the top 5 occurrence keywords. Discussion: Since 2013, SE and cancer related publications have shown a rapid growth trend. The United States continues to play a leading role in this field, as the top literature numbers, affiliations, funding agencies, and authors were all from the United States, followed by China and European countries. A high degree of active cooperation is evident among a multitude of countries. The role of SEs in cell identity, gene transcription, expression, and inhibition, as well as the relationship between SEs and TFs, and the selective inhibition of SEs, have received much attention, suggesting that they are hot issues for research.

Keywords: bibliometric analysis; cancer; hot spots; super-enhancer; trends.

Publication types

Systematic Review